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12 Days of Brain Health Research Papers

12/16/2025

 
On the first day of December, and every other day of the year, the Brain Health ARC shared a vision to make Scotland the world leader for brain health discovery. Catch up on a selection of handpicked papers from the Brain Health ARC team:
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  • Feline cognitive dysfunction syndrome (feline dementia) is a clinical disorder observed in elderly cats, similar to human dementia. Read here.
  • The care experience of people with diagnosed or suspected dementia living in prison: A case study approach. Read here.
  • Associations and interactions between APOE e4 genotype and lifestyle with brain structural phenotypes, with collaboration from across the Brain Health ARC team. Read here.
  • Cardiovascular Risk as a Moderator of the Relationship of Plasma Alzheimer’s Disease Biomarkers with Cognitive Status. Read here.
  • Intimate partner violence, traumatic brain injury and long-term mental health outcomes in midlife: the Drake IPV study
  • BBC: Obesity jab drug fails to slow Alzheimer's. Read here.
  • Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank. Read here.
  • Pan-Scotland audit of delirium in hospitals: Delirium assessment, management and barriers to effective care across Scotland: A secondary analysis of survey data from World Delirium Awareness Day 2023.  Read here.
  • Mechanisms underlying neurocognitive dysfunction following critical illness: a systematic review
  • 2022 Ageing-related Grants Dataset from the Vivensa Foundation 2025 report
  • US Pointer (a study of multi-component lifestyle interventions for preventing dementia). Read Terry Quinn’s summary here.
  • ​Alzheimer’s Society’s paper on public health impact of Alzheimer's disease and the ramifications for family caregivers, the dementia workforce, and society. Read here. 
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Top Ten Research Priorities

12/5/2025

 
Dementia and other brain health challenges are global issues, but they benefit from local, context-specific solutions. With limited resources, and an almost overwhelming number of potential research directions, how do we decide which research projects to support in Scotland?

With the help of Fenna Lunter, a fantastic visiting researcher from Netherlands, and a steering board of professionals and experts through lived experience, we asked the people of Scotland to help us define the most important questions for future research.
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Between April and July 2025, 706 people submitted 2,677 potential research questions. We received responses from people living with dementia, caregivers, clinicians, researchers, the third sector, and beyond. Using surveys, and priority ranking, we eventually agreed on a ‘top ten’ list of priority research questions for brain health and another ‘top ten’ for dementia.

How to facilitate earlier diagnosis led the dementia priorities, while improving risk reduction was the primary brain health priority. In terms of potential impact, research questions around understanding brain resilience and redesigning dementia care pathways were selected.
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We hope that some of the questions will become commissioned research calls. Perhaps some of our Brain Health ARC community want to tackle the questions in the top ten - get in touch for guidance!
read more
Top 10 Research Priorities in Brain Health
1. How much can people – especially those with high genetic or other risk for dementia – reduce their risk?
2. What brain stimulating and lifelong learning activities are beneficial for brain health? (including amount, types, variety, and suitability for different ages/abilities)
3. How can we financially prepare our health care system for the future, considering the ageing population?
3. How can we financially prepare our health care system for the future, considering the ageing population?
5. What is the role of diet in brain health and how can we intervene (during different stages of the life course and specific types of food/drink - olike ultra processed food)
6. What is the role of sleep in brain health and how can we intervene?
7. What is the role of physical activity in brain health and how can we intervene? (including amount and types of exercise)
8. What is the role of stress and anxiety in brain health and how can we intervene? (including different sources, amounts and length of exposure)
9. What are population-wide interventions to benefit brain health that can be done during childhood, mid-life and old age populations?
10. Why do some people – especially those with high genetic or other risk on paper – keep good brain health in reality? (including brain resilience)

Top 10 Research Priorities in Dementia
1. What are ways to diagnose dementia earlier than in current practice? (including identifying key early symptoms and biomarkers)
2. What new treatments for preventing or stopping dementia can be developed? (including acceptable side effects, optimal timing, applicability for subtypes of dementia)
3. How can we optimise the brain health and dementia care path in Scotland? (including personalisation, ensuring follow-up, designing new 'memory clinics', and cross-disciplinary links)
4. Are there existing drugs that can be repurposed to help prevent dementia?
5. What support can be given to let people live independently and/or at home as long as possible?
6. How can we improve care for people living with advanced dementia in order to maintain their quality of life?
7. What support do caregivers need and do the current services meet their (different) needs?
8. How can we ensure that all health and social care professionals, not just dementia specialists, provide dementia friendly care?
9. How can brain scans best be used in brain health care? (including predicting dementia risk and following brain changes over time)
10. What can we learn from other countries' dementia and brain health care systems? (including assisted dying law)

Arlene Bunton attends Global Ageing Network Summit 2025

12/2/2025

 
The Brain Health ARC supported Arlene in attending The Global Ageing Network Summit (GAN) in Boston in October, joining leaders, researchers, and practitioners to explore innovation, equity, and dignity in ageing.

I am a doctoral student in Applied Social Research at Stirling University studying Dementia and Ageing, specifically the intersectionality of identities in spousal care partnerships where one partner has dementia. I was invited to present my research at the Ageing Commons and display my poster. After attending GAN 2023 in Glasgow I was determined to go and gratefully received funding from the Brain Health ARC to attend. I hoped to leave feeling enthused, empowered, and eager to continue working within the field with a renewed energy so close to completion of my doctorate, and it certainly delivered that! These are my insights from across the three-day summit:
read more
Day One – Innovation in Aged Care
Vic Rayner OBE highlighted the urgency of embracing technology and AI without leaving older adults behind. Dr Joe Coughlin (MIT AgeLab) reframed ageing as a shared journey, not “about them but about us,” introducing the Quality Aging Needs pyramid - health, safety, connection, contribution, and legacy - as a framework for inclusive innovation. Tools like the AGNES empathy suit and Boston’s “living lab” showed how design can foster independence and inclusion.

Day Two – Research and Practice
Panels explored how the built environment prevents falls, with flooring, lighting, and passive tech shaping safety and wellbeing. In the Ageing Commons, I showcased my doctoral research on dementia care emphasised by the dyadic lens - seeing couples as units of care shaped by identity, emotion, and equity. Other presentations showcased decision aids for self-funders, disparities in service use across residence types, and the role of creative activities, nutrition, and technology in sustaining cognitive health and social connection.

Day Three – Sector Insights and Workforce Futures
Research highlighted the persistence of ageism in healthcare and community life, calling for education and advocacy. Studies on assisted living underscored the importance of smaller, non-profit models and registered nurse staffing. Nurse-led wellness programs in affordable housing reduced isolation and improved health, while rural ageing research revealed stark disparities in transport, food, and housing. Technology pilots like LifeLoop boosted staff satisfaction, while community health workers in Hawaii bridged cultural and systemic gaps. Workforce studies stressed onboarding, support, smarter scheduling, and career pathways as keys to retaining CNAs and HHAs.

Takeaway
Across all sessions, a clear message emerged: ageing is not decline but possibility. Innovation must be co-produced with older adults, embedding rights, equity, and dignity. Whether through design, technology, workforce reform, or relational care, the summit called on us to be “cathedral builders” - creating systems that honour ageing as a stage of life rich with purpose, connection, and legacy.

Brain Health ARC visits the ReALity Institute in Mainz, Germany

12/2/2025

 
In November, a Scottish delegation of neuroscientists, sponsored by the Brain Health ARC, were welcomed to the ReALity Institute in Mainz to present their work and develop new collaborations.

The workshop, titled Molecular Communication in Brain Health, is part of a series between the “Scotland Hub” and the ReALity Institute, designed to promote connections between Scotland and the Rheinland-Pfalz region of Germany.

The Scottish delegation included Prof Frank Gunn-Moore (University of St Andrews and the Brain Health ARC), Dr Rosie Jackson (University of Dundee), Dr Philip Hasel (University of Edinburgh), Prof Jenna Gregory (University of Aberdeen), and Dr Fiona Kerr (Edinburgh Napier University and the Brain Health ARC).

Prof Frank Gunn-Moore said: "It was a great meeting showcasing the excellent research in these two centres ranging from the molecular to the clinical, from new diagnosis methods to potential treatments. As ever, we were extremely well looked after; sampling both local wine and beer, and the largest schnitzels that any of us had ever seen."
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The Brain Health Alliance for Research Challenges is supported by the Scottish Funding Council.
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